Advantix II for Dogs: A Comprehensive Guide

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As a dog owner, it’s your responsibility to protect your furry friend from pesky and dangerous parasites like fleas, ticks, and mosquitoes. That’s where Advantix II comes in – a popular and effective flea and tick preventative treatment for dogs. In this article, we’ll discuss everything you need to know about Advantix II for dogs, including its ingredients, how it works, and how to use it.

What is Advantix II?

Advantix II is a topical solution for dogs that kills and repels fleas, ticks, and mosquitoes. The product is waterproof, meaning it remains effective even if your dog gets wet. The active ingredients in Advantix II are imidacloprid, permethrin, and pyriproxyfen. Imidacloprid and permethrin are insecticides that kill adult fleas, ticks, and mosquitoes. Pyriproxyfen is an insect growth regulator that prevents flea eggs from hatching.

How does Advantix II work?

When applied, Advantix II spreads over your dog’s skin and through the hair coat. The active ingredients then enter the oil glands of the skin, where they are released over time to provide continuous protection against fleas, ticks, and mosquitoes. Advantix II kills fleas and ticks on contact, meaning they don’t have to bite your dog to die. It also repels ticks and mosquitoes, which can help reduce the risk of your dog getting diseases like Lyme disease and heartworm.

How to Use Advantix II

Advantix II comes in different sizes based on your dog’s weight. Be sure to read and follow the product label carefully. To use Advantix II, follow these steps:

  1. Part the hair on the back of your dog’s neck to expose the skin.
  2. Place the tip of the applicator on the skin and squeeze out the entire contents of the tube.
  3. Apply the solution evenly to three or four spots on your dog’s neck and along the back from the shoulder to the base of the tail.
  4. Avoid applying the solution near the dog’s mouth, eyes, or open wounds.
  5. Do not let your dog get wet for at least 24 hours after applying Advantix II.

Advantages of Using Advantix II

Advantix II is a popular and effective flea and tick preventative treatment for dogs. Here are some advantages of using Advantix II:

  • Kills fleas, ticks, and mosquitoes
  • Repels ticks and mosquitoes
  • Waterproof – remains effective even after swimming or bathing
  • Easy to apply – simply squeeze the contents onto the skin
  • Protects against flea infestations by preventing flea eggs from hatching

Side Effects of Advantix II

While Advantix II is generally safe, some dogs may experience side effects. These can include:

  • Skin irritation, redness, or itching at the application site
  • Hair loss at the application site
  • Vomiting or diarrhea if the dog ingests the product
  • Lethargy or agitation
  • Tremors or seizures (in rare cases)

If you notice any of these side effects, contact your veterinarian immediately.

FAQs about Advantix II

  1. How often should I use Advantix II?
  2. Advantix II should be applied once a month.

  3. Can I use Advantix II on my cat?
  4. No, Advantix II is for use on dogs only. Cats can be highly sensitive to permethrin, one of the active ingredients in Advantix II, and it can be fatal to them.

  5. Can I use Advantix II on my puppy?
  6. Advantix II can be used on puppies as young as 7 weeks old and weighing over 3 lbs.

  7. What if my dog licks or ingests Advantix II?
  8. If your dog licks or ingests Advantix II, contact your veterinarian immediately.

  9. Can I bathe my dog after applying Advantix II?
  10. You should not bathe your dog for at least 24 hours after applying Advantix II, as this may reduce its effectiveness.


Advantix II is a popular and effective flea and tick preventative treatment for dogs. By following the instructions carefully, you can keep your dog protected from fleas, ticks, and mosquitoes. Remember to monitor your dog for any side effects and contact your veterinarian if you notice any unusual behavior.